NH-3 [Ligand Id: 2633] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL109279 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] | ||||||||
| ChEMBL | Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3 | B | 7.03 | pKd | 93 | nM | Kd | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
| GtoPdb | - | - | 7.62 | pKd | - | - | - | J Med Chem (2002) 45: 3310-20 [PMID:12109914] |
| ChEMBL | Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1) | B | 6.02 | pIC50 | 950 | nM | IC50 | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
| Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] | ||||||||
| GtoPdb | - | - | 7.03 | pKd | - | - | - | J Med Chem (2002) 45: 3310-20 [PMID:12109914] |
| ChEMBL | Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3 | B | 7.7 | pKd | 20 | nM | Kd | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
| ChEMBL | Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1) | B | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (2002) 45: 3310-3320 [PMID:12109914] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
