[3H]GR 113808 [Ligand Id: 259] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL518682 (GR-113808)
  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • 5-HT4 receptor in Rat [GtoPdb: 9] [UniProtKB: Q62758]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Binding affinity to human 5HT4 receptor expressed in HEK293 cells by saturation binding method B 7.8 pKd 15.81 nM Kd J Nat Prod (2006) 69: 1421-1424 [PMID:17067154]
GtoPdb - - 10.3 pKd 0.05 nM Kd J Neurochem (1997) 69: 1810-9 [PMID:9349523];
J Neurochem (2000) 74: 478-89 [PMID:10646498];
Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 146-60 [PMID:11218067];
Br J Pharmacol (2000) 130: 527-38 [PMID:10821780]
5-HT4 receptor in Rat [GtoPdb: 9] [UniProtKB: Q62758]
GtoPdb - - 9.3 pKd - - - Eur J Pharmacol (1996) 304: 231-5 [PMID:8813606];
Neuropharmacology (1997) 36: 671-9 [PMID:9225293]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]