azimilide [Ligand Id: 2588] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL123558 (Azimilida, Azimilide)
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  • Potassium voltage-gated channel subfamily H member 2 in Guinea pig [ChEMBL: CHEMBL5557] [UniProtKB: O08703]
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  • Voltage-gated potassium channel subunit Kv7.1 in Guinea pig [ChEMBL: CHEMBL5135] [UniProtKB: O70344]
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  • Kv7.1 in Mouse [GtoPdb: 560] [UniProtKB: P97414]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibitory concentration against potassium channel HERG B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibition of human ERG B 6.25 pIC50 562.34 nM IC50 Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL Inhibition of human ERG in MCF7 cells B 6.25 pIC50 562.34 nM IC50 Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1 F 6.25 pIC50 560 nM IC50 J Med Chem (2002) 45: 3844-3853 [PMID:12190308]
ChEMBL Inhibitory concentration against IKr potassium channel B 6.4 pIC50 400 nM IC50 Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
Potassium voltage-gated channel subfamily H member 2 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5557] [UniProtKB: O08703]
ChEMBL Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp technique B 6.74 pIC50 180 nM IC50 Bioorg Med Chem Lett (2009) 19: 1477-1480 [PMID:19185489]
Voltage-gated potassium channel subunit Kv7.1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5135] [UniProtKB: O70344]
ChEMBL Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-clamp technique B 6.62 pIC50 240 nM IC50 Bioorg Med Chem Lett (2009) 19: 1477-1480 [PMID:19185489]
Kv7.1 in Mouse [GtoPdb: 560] [UniProtKB: P97414]
GtoPdb - - 5.3 pIC50 - - - Br J Pharmacol (1997) 122: 187-9 [PMID:9313924]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]