4α-PDD [Ligand Id: 2500] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL118987 (4Alpha-Phorbol-Didecanoate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPV4 in Human [GtoPdb: 510] [UniProtKB: Q9HBA0] | ||||||||
| GtoPdb | - | - | 6.5 | pEC50 | - | - | - | Br J Pharmacol (2003) 140: 413-21 [PMID:12970074] |
| TRPV4/Transient receptor potential cation channel subfamily V member 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6126] [GtoPdb: 510] [UniProtKB: Q9EPK8] | ||||||||
| ChEMBL | Activation of mouse TRPV4 Y556A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 5.2 | pEC50 | 6300 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Activation of mouse TRPV4 W586A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 5.22 | pEC50 | >6000 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 6.43 | pEC50 | 370 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| ChEMBL | Agonist activity at mouse TRPV4 | B | 6.43 | pEC50 | 370 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 127022-127022 [PMID:32063431] |
| ChEMBL | Activation of mouse TRPV4 S557A mutant expressed in HEK293 cells assessed as increase in intracellular calcium concentration | B | 6.49 | pEC50 | 320 | nM | EC50 | J Med Chem (2009) 52: 2933-2939 [PMID:19361196] |
| GtoPdb | - | - | 6.7 | pEC50 | - | - | - | J Biol Chem (2002) 277: 13569-77 [PMID:11827975] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
