ChEMBL ligand: CHEMBL293492 (Abion ca, .beta.-phenylacrolein, Cinnamal, Cinnamaldehyde, Cinnamic aldehyde, FEMA NO. 2286, NSC-16935, NSC-40346, XC-800, Zimtaldehyde)
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!
Cell division protein ftsZ in Escherichia coli [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC method	B	4.46	pIC50	35000	nM	IC50	Bioorg Med Chem (2019) 27: 3745-3759 [PMID:31331653]
Cell division protein ftsZ in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
ChEMBL	Inhibition of Escherichia coli FtsZ polymerization	B	5.16	pIC50	6860	nM	IC50	Eur J Med Chem (2015) 95: 1-15 [PMID:25791674]
ChEMBL	Inhibition of Escherichia coli FtsZ GTPase activity	B	5.24	pIC50	5810	nM	IC50	Eur J Med Chem (2015) 95: 1-15 [PMID:25791674]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count	F	4.29	pEC50	51400	nM	EC50	Bioorg Med Chem Lett (2010) 20: 276-279 [PMID:19945872]
ChEMBL	Activation of TRPA1	B	4.72	pEC50	19000	nM	EC50	Nature (2007) 445: 541-545 [PMID:17237762]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	5.05	pEC50	9000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	5.07	pEC50	8511.38	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels	B	5.19	pEC50	6500	nM	EC50	J Med Chem (2010) 53: 5085-5107 [PMID:20356305]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
GtoPdb	-	-	4.2	pEC50	63000	nM	EC50	Neuron (2004) 41: 849-57 [PMID:15046718]
ChEMBL	Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis	B	4.21	pEC50	61000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]