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ChEMBL ligand: CHEMBL1908355 (CP-66,248, CP-66248, Tenidap) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
ChEMBL | In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1) cells | B | 5.05 | pIC50 | 9000 | nM | IC50 | J Med Chem (1990) 33: 2019-2024 [PMID:2113951] |
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 7.26 | pIC50 | 55 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Cyclooxygenase-1 in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3334] [UniProtKB: O97554] | ||||||||
ChEMBL | Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of calcium ionophore A23187 | B | 5.59 | pIC50 | 2560 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7349-7353 [PMID:21055929] |
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
ChEMBL | DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) | B | 6.57 | pIC50 | 267 | nM | IC50 | DrugMatrix in vitro pharmacology data |
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 6 | pIC50 | 1000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 6.15 | pIC50 | 700 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Prostaglandin G/H synthase 2 in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293198] [UniProtKB: O02768] | ||||||||
ChEMBL | Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of calcium ionophore A23188 and lipopolysaccharide | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7349-7353 [PMID:21055929] |
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050] | ||||||||
GtoPdb | - | - | 6.4 | pEC50 | - | - | - | Eur J Pharmacol (2002) 435: 153-60 [PMID:11821021] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]