ChEMBL ligand: CHEMBL525408 (Apamin)
KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952] KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Rat [ChEMBL: CHEMBL3743] [GtoPdb: 381] [UniProtKB: P70606] There should be some charts here, you may need to enable JavaScript!
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6] KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605] There should be some charts here, you may need to enable JavaScript!
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2369] [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb	-	-	8.48	pIC50	3.3	nM	IC50	Br J Pharmacol (2000) 129: 627-30 [PMID:10683185]; Toxicon (2004) 43: 933-49 [PMID:15208027]; Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]
ChEMBL	Displacement of radiolabeled apamin from calcium-activated SK channel	B	10.85	pIC50	0.01	nM	IC50	J Med Chem (2008) 51: 7094-7098 [PMID:18983139]
KCa2.1/Small conductance calcium-activated potassium channel protein 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3743] [GtoPdb: 381] [UniProtKB: P70606]
ChEMBL	Inhibition of rat SK Calcium channel	B	10.62	pIC50	0.02	nM	IC50	Bioorg Med Chem (2010) 18: 7675-7699 [PMID:20875743]
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3381] [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb	-	-	9.1	pIC50	0.8	nM	IC50	Neuropharmacology (2001) 40: 772-83 [PMID:11369031]; Mol Pharmacol (2004) 65: 788-801 [PMID:14978258]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	B	9.77	pIC50	0.17	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5694-5697 [PMID:18824351]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	B	9.77	pIC50	0.17	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5316-5319 [PMID:18774291]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay	B	10.19	pIC50	0.06	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5694-5697 [PMID:18824351]
ChEMBL	Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay	B	10.19	pIC50	0.06	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5316-5319 [PMID:18774291]
KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605]
GtoPdb	-	-	9.2	pIC50	-	-	-	Am J Physiol, Cell Physiol (2001) 280: C836-42 [PMID:11245600]; J Physiol (Lond.) (2001) 535: 323-34 [PMID:11533126]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb	-	-	9.4	pKd	0.3	nM	Kd	FEBS Lett (2000) 469: 196-202 [PMID:10713270]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb	-	-	10.2	pIC50	-	-	-	Science (1996) 273: 1709-14 [PMID:8781233]; Br J Pharmacol (2000) 129: 991-9 [PMID:10696100]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]