flindokalner [Ligand Id: 2307] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL266510 (BMS-204352, BMS-204352-01, Flindokalner) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa1.1/Calcium-activated potassium channel subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4304] [GtoPdb: 380] [UniProtKB: Q12791] | ||||||||
| ChEMBL | Positive modulation of Kca 1.1 (unknown origin) | B | 6.45 | pEC50 | 352 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| GtoPdb | - | - | 6.5 | pEC50 | - | - | - | Nat Med (2001) 7: 471-7 [PMID:11283675] |
| Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | Neuropharmacology (2001) 40: 888-98 [PMID:11378159] |
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.2 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.3/Voltage-gated potassium channel subunit Kv7.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2684] [GtoPdb: 562] [UniProtKB: O43525] | ||||||||
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.3 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | Am J Physiol, Cell Physiol (2001) 280: C859-66 [PMID:11245603] |
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
| Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82] | ||||||||
| GtoPdb | - | - | 5.6 | pEC50 | - | - | - | Eur J Pharmacol (2002) 437: 129-37 [PMID:11890900] |
| ChEMBL | Positive modulatory activity at voltage-gated K channel 7.5 (unknown origin) | B | 5.62 | pEC50 | 2400 | nM | EC50 | J Med Chem (2013) 56: 593-624 [PMID:23121096] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
