[3H]GR65630 [Ligand Id: 2303] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL122903 (GR-65630)
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  • 5-HT3A in Human [GtoPdb: 379]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Potency to 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand in rat cortex B 8.79 pKi 1.62 nM Ki J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373374] [UniProtKB: P35563Q9JJ16]
ChEMBL Displacement of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes B 9.55 pKi 0.28 nM Ki J. Med. Chem. (1993) 36: 3693-3699 [PMID:8246239]
5-HT3A in Human [GtoPdb: 379]
GtoPdb - - 9.32 pKd 0.48 nM Kd Mol Pharmacol (1998) 53: 202-12 [PMID:9463477];
J Pharmacol Sci (2007) 104: 263-73 [PMID:17652911]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]