ChEMBL ligand: CHEMBL47244 (Picrotoxinin)
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416] glycine receptor α2 subunit/Glycine receptor subunit alpha-2 in Rat [ChEMBL: CHEMBL2328] [GtoPdb: 424] [UniProtKB: P22771] There should be some charts here, you may need to enable JavaScript!
5-HT3AB in Human [GtoPdb: 378] There should be some charts here, you may need to enable JavaScript!
5-HT3A in Human [GtoPdb: 379] There should be some charts here, you may need to enable JavaScript!
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] There should be some charts here, you may need to enable JavaScript!
glycine receptor α3 subunit in Human [GtoPdb: 425] [UniProtKB: O75311] There should be some charts here, you may need to enable JavaScript!
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167] There should be some charts here, you may need to enable JavaScript!
Glycine Receptor (All subtypes) in Human [GtoPdb: 428] There should be some charts here, you may need to enable JavaScript!
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8] There should be some charts here, you may need to enable JavaScript!
TAS2R46 in Human [GtoPdb: 679] [UniProtKB: P59540] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
GtoPdb	-	-	6.4	pIC50	410	nM	IC50
glycine receptor α2 subunit/Glycine receptor subunit alpha-2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2328] [GtoPdb: 424] [UniProtKB: P22771]
ChEMBL	Inhibition of rat alpha2 homomeric glycine receptor expressed in CHO cells assessed as inhibition of 300 uM glycine-elicited current by outside patch clamp technique	B	5.62	pIC50	2400	nM	IC50	J Biol Chem (2007) 282: 16016-16035 [PMID:17405877]
5-HT3AB in Human [GtoPdb: 378]
GtoPdb	-	-	4.2	pIC50	63000	nM	IC50	Neuropharmacology (2011) 60: 488-95 [PMID:21059362]
5-HT3A in Human [GtoPdb: 379]
GtoPdb	-	-	4.96	pIC50	11000	nM	IC50	Mol Pharmacol (2011) 80: 183-90 [PMID:21505038]
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
GtoPdb	-	-	5.3	pIC50	5100	nM	IC50
glycine receptor α3 subunit in Human [GtoPdb: 425] [UniProtKB: O75311]
GtoPdb	-	-	6.4	pIC50	430	nM	IC50
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167]
GtoPdb	-	-	4.6	pIC50	27000	nM	IC50
GtoPdb	-	-	5.1	pIC50	8900	nM	IC50
Glycine Receptor (All subtypes) in Human [GtoPdb: 428]
GtoPdb	-	-	5.3	pIC50	-	-	-	EMBO J (1992) 11: 4305-11 [PMID:1385113]; J Biol Chem (1995) 270: 13799-806 [PMID:7775436]; J Neurochem (2007) 103: 580-9 [PMID:17714449]
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8]
GtoPdb	-	-	4.74	pEC50	18000	nM	EC50	Biochem Biophys Res Commun (2004) 319: 479-85 [PMID:15178431]
TAS2R46 in Human [GtoPdb: 679] [UniProtKB: P59540]
GtoPdb	-	-	4.15	pEC50	70000	nM	EC50	J Agric Food Chem (2007) 55: 6236-43 [PMID:17595105]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]