1-phenylbiguanide [Ligand Id: 2284] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL13791 (1-Phenylbiguanide, N-Phenylimidodicarbonimidic Diamide, Phenyl Biguanide)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • 5-HT3AB in Human [GtoPdb: 378]
There should be some charts here, you may need to enable JavaScript!
  • 5-HT3A in Human [GtoPdb: 379]
  • 5-HT3A in Mouse [GtoPdb: 379]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 4.9 pIC50 12589.25 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells B 5.92 pKi 1200 nM Ki J. Med. Chem. (1996) 39: 4017-4026 [PMID:8831767]
ChEMBL Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]GR-65630 radioligand. B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1599-1603 [PMID:11412989]
ChEMBL Binding affinity towards 5-hydroxytryptamine 3 receptor B 5.92 pKi 1200 nM Ki Bioorg. Med. Chem. Lett. (2002) 12: 2743-2747 [PMID:12217367]
TAAR5/Trace amine-associated receptor 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784908] [GtoPdb: 170] [UniProtKB: Q5QD14]
ChEMBL Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assay F 5 pEC50 >10000 nM EC50 Eur J Med Chem (2017) 127: 781-792 [PMID:27823885]
5-HT3AB in Human [GtoPdb: 378]
GtoPdb - - 4.9 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465]
5-HT3A in Human [GtoPdb: 379]
GtoPdb - - 5.6 pKi - - - Mol Pharmacol (1995) 48: 407-16 [PMID:7565620];
Mol Pharmacol (1998) 53: 202-12 [PMID:9463477];
Neuropharmacology (2001) 41: 282-4 [PMID:11489465];
J Neurochem (1995) 65: 104-10 [PMID:7790853];
Br J Pharmacol (1996) 118: 1237-45 [PMID:8818349]
GtoPdb - - 4.1 pEC50 80000 nM EC50 Mol Pharmacol (1995) 48: 1054-62 [PMID:8848005]
5-HT3A in Mouse [GtoPdb: 379]
GtoPdb - - 6.2 pKi - - - J Neurochem (1995) 65: 104-10 [PMID:7790853]
GtoPdb - - 4.5 pEC50 - - - Neuropharmacology (1994) 33: 473-82 [PMID:7984286]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]