L-367,773 [Ligand Id: 2246] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL338522 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Tested against human uterine OT receptor | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Life Sci (1995) 57: 2253-61 [PMID:7475979] |
| OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] | ||||||||
| ChEMBL | Tested against rat uterine OT receptor | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
| ChEMBL | Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue | B | 7.28 | pIC50 | 52 | nM | IC50 | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
| V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] | ||||||||
| ChEMBL | Inhibition of radioligand [3H]-AVP binding to the vasopressin V2 receptor in rat kidney tissue | B | 4.77 | pIC50 | 17000 | nM | IC50 | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
