YM 471 [Ligand Id: 2205] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL307483 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Br J Pharmacol (2001) 133: 746-54 [PMID:11429400] |
| ChEMBL | Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand | B | 9.21 | pKi | 0.62 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] | ||||||||
| ChEMBL | Evaluated for the binding affinity towards vasopressin (V1A) receptor in rat liver membrane using [3H]AVP as radioligand | B | 9.21 | pKi | 0.62 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 229-232 [PMID:11755361] |
| ChEMBL | Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver | B | 9.8 | pKi | 0.16 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| GtoPdb | - | - | 8.9 | pKi | - | - | - | Br J Pharmacol (2001) 133: 746-54 [PMID:11429400] |
| ChEMBL | Binding affinity at cloned human Vasopressin V2 receptor stably expressed in CHO cells, using [3H]AVP as radioligand | B | 8.92 | pKi | 1.19 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] | ||||||||
| ChEMBL | Evaluated for the binding affinity towards vasopressin (V2) receptor in rat kidney membrane using [3H]AVP as radioligand | B | 8.92 | pKi | 1.19 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 229-232 [PMID:11755361] |
| ChEMBL | Binding affinity at Vasopressin V2 receptor, performed using [3H]AVP on rat kidney | B | 9.11 | pKi | 0.77 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | Br J Pharmacol (2001) 133: 746-54 [PMID:11429400] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
