LS-192629 [Ligand Id: 2192] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1254024 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Displacement of [3H]-oxytocin from human oxytocin receptor expressed in CHO cells | B | 7.55 | pKi | 28 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| ChEMBL | Displacement of [3H]-oxytocin from oxytocin receptor in human uterus tissue | B | 7.55 | pKi | 28 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| GtoPdb | - | - | 7.8 | pKi | - | - | - | J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315] |
| OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] | ||||||||
| ChEMBL | Antagonist activity at oxytocin receptor in rat uterine strips assessed as inhibition of oxytocin-induced contraction | F | 7.8 | pKd | 15.85 | nM | Kd | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| ChEMBL | Displacement of [3H]-oxytocin from rat oxytocin receptor expressed in CHO cells | B | 6.87 | pKi | 135 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| GtoPdb | - | - | 6.9 | pKi | - | - | - | J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315] |
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| GtoPdb | - | - | 6.7 | pKi | - | - | - | J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315] |
| ChEMBL | Displacement of [3H]vasopressin from human vasopressin V1a receptor expressed in CHO cells | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| ChEMBL | Displacement of [3H]vasopressin from human vasopressin V2 receptor expressed in CHO cells | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2010) 53: 6525-6538 [PMID:20550119] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
