N′,2-diphenylquinoline-4-carbohydrazide [Ligand Id: 2129] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL219162 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Inhibition of human NK1 receptor | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
| ChEMBL | Inhibition of human NK2 receptor | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| ChEMBL | Activity at human NK3 receptor assessed as inhibition of senktide-induced calcium mobilization in CHO cells at 2.8 uM | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| ChEMBL | Activity at human NK3 receptor assessed as inhibition of senktide-stimulated inositol phosphate generation in CHO cells | F | 7.55 | pIC50 | 28 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| ChEMBL | Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cells | B | 8.06 | pIC50 | 8.8 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| ChEMBL | Binding affinity to gerbil NK3 receptor | B | 8.35 | pIC50 | 4.5 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Bioorg Med Chem Lett (2006) 16: 5748-51 [PMID:16950620] |
| NK3 receptor/Neurokinin 3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3154] [GtoPdb: 362] [UniProtKB: P16177] | ||||||||
| ChEMBL | Binding affinity to rat NK3 receptor | B | 7.18 | pIC50 | 66 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
