eledoisin [Ligand Id: 2086] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL373569 (ELD 950, ELD-950, Eledoisin, Eledoisina, Eledoisine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | 264.2 | nM | IC50 |
J Biol Chem (1996) 271: 20250-7 [PMID:8702757]; FEBS Lett (1992) 299: 90-5 [PMID:1312036] |
| ChEMBL | Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis | B | 7.02 | pIC50 | 96 | nM | IC50 | Bioorg Med Chem (2013) 21: 2413-2417 [PMID:23473945] |
| ChEMBL | Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation | F | 8.18 | pEC50 | 6.6 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5752-5756 [PMID:16950617] |
| ChEMBL | Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells | F | 8.24 | pEC50 | 5.7 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5748-5751 [PMID:16950620] |
| ChEMBL | Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM | F | 9.66 | pEC50 | 0.22 | nM | EC50 | Bioorg Med Chem (2013) 21: 2413-2417 [PMID:23473945] |
| NK1 receptor in Human [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| GtoPdb | - | - | 8.6 | pIC50 | - | - | - | J Biol Chem (1996) 271: 20250-7 [PMID:8702757] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
