octreotide [Ligand Id: 2055] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL262746
  • SST2 receptor in Human [GtoPdb: 356] [UniProtKB: P30874]
  • SST2 receptor in Mouse [GtoPdb: 356] [UniProtKB: P30875]
  • SST2 receptor in Rat [GtoPdb: 356] [UniProtKB: P30680]
Created with Highcharts 10.3.3ValuesChart context menuSST2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 MousepKd RatpKi RatpIC50 RatpEC50 Rat024681012Highcharts.com
  • SST3 receptor in Human [GtoPdb: 357] [UniProtKB: P32745]
  • SST3 receptor in Mouse [GtoPdb: 357] [UniProtKB: P30935]
  • SST3 receptor in Rat [GtoPdb: 357] [UniProtKB: P30936]
Created with Highcharts 10.3.3ValuesChart context menuSST3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 MousepKd RatpKi RatpIC50 RatpEC50 Rat0246810Highcharts.com
  • SST5 receptor in Human [GtoPdb: 359] [UniProtKB: P35346]
  • SST5 receptor in Mouse [GtoPdb: 359] [UniProtKB: O08858]
  • SST5 receptor in Rat [GtoPdb: 359] [UniProtKB: P30938]
Created with Highcharts 10.3.3ValuesChart context menuSST5 receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd MousepKi MousepIC50 MousepEC50 MousepKd RatpKi RatpIC50 RatpEC50 Rat024681012Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SST2 receptor in Human [GtoPdb: 356] [UniProtKB: P30874]
GtoPdb - - 9.9 pKi - - - Metab Clin Exp (1996) 45: 17-20 [PMID:8769372];
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788];
Endocrinology (1994) 135: 2814-7 [PMID:7988476];
Proc Natl Acad Sci USA (1998) 95: 10836-41 [PMID:9724791];
Eur J Pharmacol (1998) 348: 311-20 [PMID:9652348]
SST2 receptor in Mouse [GtoPdb: 356] [UniProtKB: P30875]
GtoPdb - - 9.2 pKi - - - Rev Physiol Biochem Pharmacol (1998) 133: 55-108 [PMID:9600011]
SST2 receptor in Rat [GtoPdb: 356] [UniProtKB: P30680]
GtoPdb - - 8.7 pKi - - - Rev Physiol Biochem Pharmacol (1998) 133: 55-108 [PMID:9600011]
SST3 receptor in Human [GtoPdb: 357] [UniProtKB: P32745]
GtoPdb - - 8.6 pKi - - - Metab Clin Exp (1996) 45: 17-20 [PMID:8769372];
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788];
Endocrinology (1994) 135: 2814-7 [PMID:7988476];
Proc Natl Acad Sci USA (1998) 95: 10836-41 [PMID:9724791];
FEBS Lett (1993) 321: 279-84 [PMID:8097479]
SST3 receptor in Mouse [GtoPdb: 357] [UniProtKB: P30935]
GtoPdb - - 8.5 pIC50 - - - Mol Pharmacol (1993) 43: 838-44 [PMID:8100350]
SST3 receptor in Rat [GtoPdb: 357] [UniProtKB: P30936]
GtoPdb - - 7.8 pKi - - - Rev Physiol Biochem Pharmacol (1998) 133: 55-108 [PMID:9600011]
SST5 receptor in Human [GtoPdb: 359] [UniProtKB: P35346]
GtoPdb - - 9.5 pKi - - - Metab Clin Exp (1996) 45: 17-20 [PMID:8769372];
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 483-9 [PMID:9650799];
Naunyn Schmiedebergs Arch Pharmacol (1999) 360: 488-99 [PMID:10598788];
Rev Physiol Biochem Pharmacol (1998) 133: 55-108 [PMID:9600011];
Endocrinology (1994) 135: 2814-7 [PMID:7988476];
Proc Natl Acad Sci USA (1998) 95: 10836-41 [PMID:9724791];
Eur J Pharmacol (1998) 348: 311-20 [PMID:9652348]
SST5 receptor in Mouse [GtoPdb: 359] [UniProtKB: O08858]
GtoPdb - - 9.9 pKi - - - Neuropharmacology (2000) 39: 1451-62 [PMID:10818261]
SST5 receptor in Rat [GtoPdb: 359] [UniProtKB: P30938]
GtoPdb - - 7.8 pKi - - - Rev Physiol Biochem Pharmacol (1998) 133: 55-108 [PMID:9600011]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]