LY334370 [Ligand Id: 20] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL101690 (LY-334370) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5HT1A receptor (unknown origin) | B | 7.66 | pKi | 22.1 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 4337-4341 [PMID:26271587] |
| ChEMBL | In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1A receptor | B | 7.66 | pKi | 22 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1A receptor | B | 7.66 | pKi | 22 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| GtoPdb | - | - | 7.8 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1B receptor | B | 6.62 | pKi | 240 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1B receptor | B | 6.62 | pKi | 240 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| ChEMBL | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting | B | 7.08 | pKi | 83 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
| 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
| ChEMBL | In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor | B | 6.37 | pKi | 430 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1D receptor | B | 6.37 | pKi | 430 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| ChEMBL | Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting | B | 6.86 | pKi | 137 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
| 5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
| ChEMBL | In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2003) 46: 3060-3071 [PMID:12825944] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1F receptor | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719] |
| ChEMBL | Binding affinity to human 5HT1F receptor by radioligand binding assay | B | 8.68 | pKi | 2.1 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 4337-4341 [PMID:26271587] |
| GtoPdb | - | - | 8.7 | pKi | 1.99 | nM | Ki | Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510] |
| ChEMBL | In vitro binding affinity for human 5-hydroxytryptamine 1F receptor | B | 8.8 | pKi | 1.6 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 167-170 [PMID:14684321] |
| ChEMBL | Binding affinity at human 5HT1F receptor | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (2008) 51: 3609-3616 [PMID:18507369] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
