LY334370 [Ligand Id: 20] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL101690
  • 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1B receptor/5-hydroxytryptamine receptor 1B in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/5-hydroxytryptamine receptor 1D in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT1F receptor/5-hydroxytryptamine receptor 1F in Human [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/5-hydroxytryptamine receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor (unknown origin) B 7.66 pKi 22.1 nM Ki Bioorg Med Chem Lett (2015) 25: 4337-4341 [PMID:26271587]
ChEMBL In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1A receptor B 7.66 pKi 22 nM Ki J Med Chem (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1A receptor B 7.66 pKi 22 nM Ki Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719]
GtoPdb - - 7.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510]
5-HT1B receptor/5-hydroxytryptamine receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1B receptor B 6.62 pKi 240 nM Ki J Med Chem (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1B receptor B 6.62 pKi 240 nM Ki Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719]
ChEMBL Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting B 7.08 pKi 83 nM Ki J Med Chem (2008) 51: 3609-3616 [PMID:18507369]
5-HT1D receptor/5-hydroxytryptamine receptor 1D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor B 6.37 pKi 430 nM Ki J Med Chem (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1D receptor B 6.37 pKi 430 nM Ki Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719]
ChEMBL Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting B 6.86 pKi 137 nM Ki J Med Chem (2008) 51: 3609-3616 [PMID:18507369]
5-HT1F receptor/5-hydroxytryptamine receptor 1F in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
ChEMBL In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor B 8.68 pKi 2.1 nM Ki J Med Chem (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1F receptor B 8.68 pKi 2.1 nM Ki Bioorg Med Chem Lett (2004) 14: 6011-6016 [PMID:15546719]
ChEMBL Binding affinity to human 5HT1F receptor by radioligand binding assay B 8.68 pKi 2.1 nM Ki Bioorg Med Chem Lett (2015) 25: 4337-4341 [PMID:26271587]
GtoPdb - - 8.7 pKi 1.99 nM Ki Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1F receptor B 8.8 pKi 1.6 nM Ki Bioorg Med Chem Lett (2004) 14: 167-170 [PMID:14684321]
ChEMBL Binding affinity at human 5HT1F receptor B 8.8 pKi 1.6 nM Ki J Med Chem (2008) 51: 3609-3616 [PMID:18507369]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]