LY334370 [Ligand Id: 20] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL101690 (LY-334370)
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor (unknown origin) B 7.66 pKi 22.1 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 4337-4341 [PMID:26271587]
ChEMBL In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1A receptor B 7.66 pKi 22 nM Ki J. Med. Chem. (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1A receptor B 7.66 pKi 22 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6011-6016 [PMID:15546719]
GtoPdb - - 7.8 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1B receptor B 6.62 pKi 240 nM Ki J. Med. Chem. (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1B receptor B 6.62 pKi 240 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6011-6016 [PMID:15546719]
ChEMBL Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation counting B 7.08 pKi 83 nM Ki J. Med. Chem. (2008) 51: 3609-3616 [PMID:18507369]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor B 6.37 pKi 430 nM Ki J. Med. Chem. (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1D receptor B 6.37 pKi 430 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6011-6016 [PMID:15546719]
ChEMBL Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting B 6.86 pKi 137 nM Ki J. Med. Chem. (2008) 51: 3609-3616 [PMID:18507369]
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
ChEMBL In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor B 8.68 pKi 2.1 nM Ki J. Med. Chem. (2003) 46: 3060-3071 [PMID:12825944]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1F receptor B 8.68 pKi 2.1 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6011-6016 [PMID:15546719]
ChEMBL Binding affinity to human 5HT1F receptor by radioligand binding assay B 8.68 pKi 2.1 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 4337-4341 [PMID:26271587]
GtoPdb - - 8.7 pKi 1.99 nM Ki Naunyn Schmiedebergs Arch Pharmacol (2005) 371: 169-77 [PMID:15900510]
ChEMBL In vitro binding affinity for human 5-hydroxytryptamine 1F receptor B 8.8 pKi 1.6 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 167-170 [PMID:14684321]
ChEMBL Binding affinity at human 5HT1F receptor B 8.8 pKi 1.6 nM Ki J. Med. Chem. (2008) 51: 3609-3616 [PMID:18507369]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]