vapiprost [Ligand Id: 1976] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL65030 (GR 32191, GR-32191, Vapiprost) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| GtoPdb | - | - | 9.4 | pKi | - | - | - |
Br J Pharmacol (1993) 110: 539-47 [PMID:8242228]; Br J Pharmacol (1989) 97: 783-94 [PMID:2527074] |
| ChEMBL | In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2067-2072 |
| TP receptor in Mouse [GtoPdb: 346] [UniProtKB: P30987] | ||||||||
| GtoPdb | - | - | 7.9 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
