13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1α [Ligand Id: 1955] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL36041
  • DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid DP receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid EP4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • FP receptor/Prostanoid FP receptor in Human [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid FP receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
Created with Highcharts 10.3.3ValuesChart context menuProstanoid IP receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
Created with Highcharts 10.3.3ValuesChart context menuThromboxane A2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells B 5 pIC50 >10000 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. B 5.87 pIC50 1360 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
ChEMBL Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=100%) F 4.72 pEC50 19000 nM EC50 Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Affinity for Prostanoid EP2 receptor expressed in CHO cells B 5.17 pIC50 6700 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Affinity for Prostanoid EP3 receptor expressed in CHO cell line B 5.51 pIC50 3100 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
ChEMBL Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<50%) F 4.7 pEC50 >20000 nM EC50 Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Affinity for Prostanoid EP4 receptor expressed in CHO cells B 5 pIC50 >10000 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
ChEMBL Affinity for human Prostanoid FP receptor expressed in COS-7 cells B 8.59 pIC50 2.6 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
GtoPdb - - 9 pIC50 - - - J Med Chem (2000) 43: 945-52 [PMID:10715159]
ChEMBL Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells B 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040]
ChEMBL Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%) F 8.05 pEC50 9 nM EC50 Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Affinity for Prostaglandin I2 receptor expressed in CHO cells B 5 pIC50 >10000 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Affinity for Prostanoid TP receptor expressed in CHO cells B 5 pIC50 >10000 nM IC50 J Med Chem (2000) 43: 945-952 [PMID:10715159]
ChEMBL Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=90%) F 5.1 pEC50 8000 nM EC50 Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]