13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1α [Ligand Id: 1955] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL36041 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. | B | 5.87 | pIC50 | 1360 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=100%) | F | 4.72 | pEC50 | 19000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Affinity for Prostanoid EP2 receptor expressed in CHO cells | B | 5.17 | pIC50 | 6700 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| ChEMBL | Affinity for Prostanoid EP3 receptor expressed in CHO cell line | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<50%) | F | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Affinity for Prostanoid EP4 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| ChEMBL | Affinity for human Prostanoid FP receptor expressed in COS-7 cells | B | 8.59 | pIC50 | 2.6 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| GtoPdb | - | - | 9 | pIC50 | - | - | - | J Med Chem (2000) 43: 945-52 [PMID:10715159] |
| ChEMBL | Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%) | F | 8.05 | pEC50 | 9 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Affinity for Prostaglandin I2 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| ChEMBL | Affinity for Prostanoid TP receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=90%) | F | 5.1 | pEC50 | 8000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
