ChEMBL ligand: CHEMBL218071 (L-798106)
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] There should be some charts here, you may need to enable JavaScript!
EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] There should be some charts here, you may need to enable JavaScript!
EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] There should be some charts here, you may need to enable JavaScript!
EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] There should be some charts here, you may need to enable JavaScript!
EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] There should be some charts here, you may need to enable JavaScript!
FP receptor/Prostanoid FP receptor in Human [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] There should be some charts here, you may need to enable JavaScript!
IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] There should be some charts here, you may need to enable JavaScript!
TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	PDSP Secondary Binding target: DRD3 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	B	6.23	pKi	582.44	nM	Ki	EUbOPEN Chemogenomics Library - PDSP Secondary Binding
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL	Binding affinity to DP receptor	B	6.3	pKi	>500	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL	Binding affinity to EP1 receptor	B	4.41	pKi	39000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL	Binding affinity to EP2 receptor	B	4.3	pKi	>50000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL	Binding affinity to EP3 receptor in presence of HSA	B	8.16	pKi	6.9	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
ChEMBL	Binding affinity to EP3 receptor	B	9.22	pKi	0.6	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
GtoPdb	-	-	9.68	pKi	0.21	nM	Ki	Bioorg Med Chem (2001) 9: 1977-84 [PMID:11504634]; Am J Physiol Renal Physiol (2008) 295: F984-94 [PMID:18632791]; Br J Pharmacol (2009) 158: 372-81 [PMID:19486006]
ChEMBL	Antagonist activity at EP3 receptor (unknown origin)	B	7.48	pIC50	33.02	nM	IC50	ACS Med Chem Lett (2023) 14: 727-736 [PMID:37312837]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL	Binding affinity to EP4 receptor	B	6.05	pKi	890	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088]
ChEMBL	Binding affinity to FP receptor	B	6.3	pKi	>500	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL	Binding affinity to IP receptor	B	6.3	pKi	>500	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL	Binding affinity to TP receptor	B	6.3	pKi	>500	nM	Ki	Bioorg Med Chem Lett (2006) 16: 5639-5642 [PMID:16931013]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]