I-BOP [Ligand Id: 1938] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2113346 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| GtoPdb | - | - | 9.32 | pKd | 0.48 | nM | Kd | J Biol Chem (1991) 266: 13752-8 [PMID:1830308] |
| ChEMBL | Binding affinity towards Thromboxane A2 receptor/Prostaglandin receptor in human platelet membranes using [125I]- as the radioligand | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1991) 34: 1511-1514 [PMID:1826745] |
| TP receptor in Mouse [GtoPdb: 346] [UniProtKB: P30987] | ||||||||
| GtoPdb | - | - | 9.3 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
| EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557] | ||||||||
| GtoPdb | - | - | 7 | pKi | 100 | nM | Ki | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
| FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - | Br J Pharmacol (1997) 122: 217-24 [PMID:9313928] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
