ONO-AE1-259 [Ligand Id: 1932] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3286796
  • IP receptor/Prostacyclin receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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  • EP1 receptor/Prostaglandin E2 receptor EP1 subtype in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
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  • EP2 receptor/Prostaglandin E2 receptor EP2 subtype in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
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  • EP3 receptor/Prostaglandin E2 receptor EP3 subtype in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
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  • EP4 receptor/Prostaglandin E2 receptor EP4 subtype in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
IP receptor/Prostacyclin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Binding affinity to prostanoid IP receptor (unknown origin) B 5 pKi 10000 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP1 receptor/Prostaglandin E2 receptor EP1 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Binding affinity to EP1 receptor (unknown origin) B 5.89 pKi 1300 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor/Prostaglandin E2 receptor EP2 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
ChEMBL Binding affinity to EP2 receptor (unknown origin) by competitive binding assay B 8.77 pKi 1.7 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL Agonist activity at EP2 receptor (unknown origin) by functional assay B 8.74 pEC50 1.8 nM EC50 J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
GtoPdb - - 8.5 pKi - - - Endocrinology (2000) 141: 1554-9 [PMID:10746663]
EP3 receptor/Prostaglandin E2 receptor EP3 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Binding affinity to EP3 receptor (unknown origin) B 5.57 pKi 2700 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP4 receptor/Prostaglandin E2 receptor EP4 subtype in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Binding affinity to EP4 receptor (unknown origin) B 5.64 pKi 2300 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]