ChEMBL ligand: CHEMBL361812 (Baynas, BAY U 3405, BAY-U-3405, EN 137774, EN-137774, Ramatroban)
DP2 receptor/G protein-coupled receptor 44 in Human [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6] DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3] There should be some charts here, you may need to enable JavaScript!
DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] There should be some charts here, you may need to enable JavaScript!
IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] There should be some charts here, you may need to enable JavaScript!
TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
ChEMBL	Inhibitory concentration for PGD2-mediated receptor activation in a fluorescence assay that measures changes in intracellular calcium	F	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
ChEMBL	Inhibitory activity for binding of PGD-2 to CRTH-2 in hCRTH-2 binding assay using HEK293 cell membranes	F	6.54	pKi	290	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
ChEMBL	Inhibitory activity for PGD2-mediated receptor activation in a fluorescence assay that measures changes in intracellular calcium	F	6.54	pKi	290	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
ChEMBL	Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assay	B	6.86	pKi	137	nM	Ki	Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375]
ChEMBL	Displacement of [3H]PGD2 from human CRTh2 receptor expressed in CHO cells	B	7.14	pKi	73	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
GtoPdb	-	-	7.4	pKi	-	-	-	Eur J Pharmacol (2005) 524: 30-7 [PMID:16256979]
ChEMBL	Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)	B	8.37	pKi	4.3	nM	Ki	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Displacement of [3H]PGD2 from human prostaglandin D2 receptor in presence of human serum albumin	B	6.12	pIC50	754	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-mediated Ca2+ flux	F	6.34	pIC50	461	nM	IC50	J Med Chem (2011) 54: 1779-1788 [PMID:21355602]
ChEMBL	Displacement of [3H]PGD2 from human prostaglandin D2 receptor	B	6.51	pIC50	311	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as effect on cAMP accumulation	F	6.68	pIC50	210	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
ChEMBL	Antagonist activity against CRTh2 receptor in human whole blood assessed as eosinophil shape change	F	6.71	pIC50	195	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
ChEMBL	Antagonist activity at human CRTH2 receptor assessed as inhibition of DK-PGD2-induced eosinophil chemotaxis	F	6.77	pIC50	169	nM	IC50	J Med Chem (2008) 51: 2227-2243 [PMID:18318469]
ChEMBL	Displacement of [3H]PGD2 from human CRTh2 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay	B	7.11	pIC50	77	nM	IC50	J Med Chem (2011) 54: 1779-1788 [PMID:21355602]
ChEMBL	Inhibition of PGD2-induced inositol phosphate formation at human chemoattractant receptor-homologous molecule expressed on TH2 cells	F	7.54	pIC50	29	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay	F	7.55	pIC50	28	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape change	F	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb	-	-	7.3	pKi	-	-	-	J Biol Chem (2005) 280: 32442-32451 [PMID:16030019]
DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
GtoPdb	-	-	7.3	pIC50	-	-	-	J Pharmacol Exp Ther (2003) 307: 518-25 [PMID:12975488]
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL	Binding affinity to prostanoid DP1 receptor	B	4.96	pKi	11020	nM	Ki	Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375]
ChEMBL	Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptor	B	5	pKi	>10000	nM	Ki	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Displacement of [3H]PGD2 from prostaglandin D1 receptor in human platelet membrane	B	4.48	pIC50	33400	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Inhibition of PGD2-induced inositol phosphate formation at human Prostaglandin D2 receptor	F	5	pIC50	>10000	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL	Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL	Inhibitory activity for binding of PGD-2 in hTP binding assay using HEK293 cell membranes	F	7.74	pKi	18	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
GtoPdb	-	-	8	pKi	-	-	-	Biochem Pharmacol (1992) 44: 495-503 [PMID:1387312]
ChEMBL	Inhibition of [3H]SQ-29,548 binding to human Thromboxane A2 receptor	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Binding affinity to thromboxane receptor	B	9.24	pKi	0.58	nM	Ki	Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375]
ChEMBL	Displacement of [3H]SQ-29548 from thromboxane receptor in human platelet membrane	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Inhibition of U-46,619-induced inositol phosphate accumulation at human Thromboxane A2 receptor	F	8.02	pIC50	9.6	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Inhibition of beta-arrestin translocation at human Thromboxane A2 receptor in BRET assay	F	8.08	pIC50	8.4	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]