ChEMBL ligand: CHEMBL361812 (Baynas, BAY U 3405, BAY-U-3405, EN 137774, EN-137774, Ramatroban)
DP2 receptor/G protein-coupled receptor 44 in Human [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6] DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3] There should be some charts here, you may need to enable JavaScript!
DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] There should be some charts here, you may need to enable JavaScript!
IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] There should be some charts here, you may need to enable JavaScript!
TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
ChEMBL	Inhibitory concentration for PGD2-mediated receptor activation in a fluorescence assay that measures changes in intracellular calcium	F	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
ChEMBL	Inhibitory activity for binding of PGD-2 to CRTH-2 in hCRTH-2 binding assay using HEK293 cell membranes	F	6.54	pKi	290	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
ChEMBL	Inhibitory activity for PGD2-mediated receptor activation in a fluorescence assay that measures changes in intracellular calcium	F	6.54	pKi	290	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
ChEMBL	Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assay	B	6.86	pKi	137	nM	Ki	Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375]
ChEMBL	Displacement of [3H]PGD2 from human CRTh2 receptor expressed in CHO cells	B	7.14	pKi	73	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
GtoPdb	-	-	7.4	pKi	-	-	-	Eur J Pharmacol (2005) 524: 30-7 [PMID:16256979]
ChEMBL	Inhibition of [3H]PGD-2 binding to human chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)	B	8.37	pKi	4.3	nM	Ki	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Displacement of [3H]PGD2 from human prostaglandin D2 receptor in presence of human serum albumin	B	6.12	pIC50	754	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-mediated Ca2+ flux	F	6.34	pIC50	461	nM	IC50	J Med Chem (2011) 54: 1779-1788 [PMID:21355602]
ChEMBL	Displacement of [3H]PGD2 from human prostaglandin D2 receptor	B	6.51	pIC50	311	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Antagonist activity against human CRTh2 receptor expressed in CHO cells assessed as effect on cAMP accumulation	F	6.68	pIC50	210	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
ChEMBL	Antagonist activity against CRTh2 receptor in human whole blood assessed as eosinophil shape change	F	6.71	pIC50	195	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
ChEMBL	Antagonist activity at human CRTH2 receptor assessed as inhibition of DK-PGD2-induced eosinophil chemotaxis	F	6.77	pIC50	169	nM	IC50	J Med Chem (2008) 51: 2227-2243 [PMID:18318469]
ChEMBL	Displacement of [3H]PGD2 from human CRTh2 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay	B	7.11	pIC50	77	nM	IC50	J Med Chem (2011) 54: 1779-1788 [PMID:21355602]
ChEMBL	Inhibition of PGD2-induced inositol phosphate formation at human chemoattractant receptor-homologous molecule expressed on TH2 cells	F	7.54	pIC50	29	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Inhibition of beta-arrestin translocation at human chemoattractant receptor-homologous molecule expressed on TH2 cells in BRET assay	F	7.55	pIC50	28	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape change	F	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4794-4798 [PMID:19592244]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb	-	-	7.3	pKi	-	-	-	J Biol Chem (2005) 280: 32442-32451 [PMID:16030019]
DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
GtoPdb	-	-	7.3	pIC50	-	-	-	J Pharmacol Exp Ther (2003) 307: 518-25 [PMID:12975488]
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
ChEMBL	Binding affinity to prostanoid DP1 receptor	B	4.96	pKi	11020	nM	Ki	Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375]
ChEMBL	Inhibition of [3H]-PGD-2 binding to human Prostaglandin D2 receptor	B	5	pKi	>10000	nM	Ki	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Displacement of [3H]PGD2 from prostaglandin D1 receptor in human platelet membrane	B	4.48	pIC50	33400	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Inhibition of PGD2-induced inositol phosphate formation at human Prostaglandin D2 receptor	F	5	pIC50	>10000	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL	Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL	Inhibitory activity for binding of PGD-2 in hTP binding assay using HEK293 cell membranes	F	7.74	pKi	18	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1749-1753 [PMID:15745833]
GtoPdb	-	-	8	pKi	-	-	-	Biochem Pharmacol (1992) 44: 495-503 [PMID:1387312]
ChEMBL	Inhibition of [3H]SQ-29,548 binding to human Thromboxane A2 receptor	B	8.35	pKi	4.5	nM	Ki	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Binding affinity to thromboxane receptor	B	9.24	pKi	0.58	nM	Ki	Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375]
ChEMBL	Displacement of [3H]SQ-29548 from thromboxane receptor in human platelet membrane	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4647-4651 [PMID:19608418]
ChEMBL	Inhibition of U-46,619-induced inositol phosphate accumulation at human Thromboxane A2 receptor	F	8.02	pIC50	9.6	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]
ChEMBL	Inhibition of beta-arrestin translocation at human Thromboxane A2 receptor in BRET assay	F	8.08	pIC50	8.4	nM	IC50	J Med Chem (2005) 48: 897-900 [PMID:15715457]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]