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ChEMBL ligand: CHEMBL276140 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
ChEMBL | Inhibition of heterologously expressed human Cytochrome P450 19A1 at 100 uM | B | 4 | pIC50 | >100000 | nM | IC50 | J. Med. Chem. (1997) 40: 3494-3496 [PMID:9357513] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
GtoPdb | - | - | 6.3 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
ChEMBL | Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells | B | 6.4 | pKi | 398.11 | nM | Ki | J. Med. Chem. (1997) 40: 3494-3496 [PMID:9357513] |
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]ketanserin as radioligand | B | 6.4 | pKi | 398.11 | nM | Ki | J. Med. Chem. (1998) 41: 1598-1612 [PMID:9572885] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells | B | 7.9 | pKi | 12.59 | nM | Ki | J. Med. Chem. (1997) 40: 3494-3496 [PMID:9357513] |
ChEMBL | Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand | B | 7.9 | pKi | 12.59 | nM | Ki | J. Med. Chem. (1998) 41: 1598-1612 [PMID:9572885] |
GtoPdb | - | - | 8.6 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Displacement of [3H]mesulergine from 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells | B | 8.6 | pKi | 2.51 | nM | Ki | J. Med. Chem. (1997) 40: 3494-3496 [PMID:9357513] |
ChEMBL | Binding affinity towards cloned human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]mesulergine as radioligand | B | 8.6 | pKi | 2.51 | nM | Ki | J. Med. Chem. (1998) 41: 1598-1612 [PMID:9572885] |
GtoPdb | - | - | 8.7 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]