[3H]PGD2 [Ligand Id: 1891] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1235252 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells | F | 7.42 | pKi | 38 | nM | Ki | Am J Physiol (1999) 277: R734-R741 [PMID:10484490] |
| OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells | F | 7.01 | pKi | 98 | nM | Ki | Am J Physiol (1999) 277: R734-R741 [PMID:10484490] |
| OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells | F | 7.35 | pKi | 45 | nM | Ki | Am J Physiol (1999) 277: R734-R741 [PMID:10484490] |
| DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| GtoPdb | - | - | 9.5 | pKd | 0.3 | nM | Kd |
Br J Pharmacol (1998) 123: 1317-24 [PMID:9579725]; Br J Pharmacol (2006) 148: 326-39 [PMID:16604093] |
| DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
| GtoPdb | - | - | 8.2 | pKd | 6 | nM | Kd |
J Pharmacol Exp Ther (2003) 307: 518-25 [PMID:12975488]; Mol Pharmacol (2006) 69: 1441-53 [PMID:16418339] |
| DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3] | ||||||||
| GtoPdb | - | - | 8 | pKd | - | - | - | J Pharmacol Exp Ther (2003) 307: 518-25 [PMID:12975488] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
