PGJ2 [Ligand Id: 1885] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1397260
  • ubiquitin C-terminal hydrolase L3/Ubiquitin carboxyl-terminal hydrolase isozyme L3 in Human [ChEMBL: CHEMBL6195] [GtoPdb: 2427] [UniProtKB: P15374]
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  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
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  • DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
  • DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ubiquitin C-terminal hydrolase L3/Ubiquitin carboxyl-terminal hydrolase isozyme L3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6195] [GtoPdb: 2427] [UniProtKB: P15374]
ChEMBL Inhibition of UCHL3 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay B 5 pIC50 10000 nM IC50 Eur J Med Chem (2022) 227: 113970-113970 [PMID:34752952]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 9 pKi - - - Br J Pharmacol (1998) 123: 1317-24 [PMID:9579725]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 8.2 pKi - - - Br J Pharmacol (2002) 137: 1163-72 [PMID:12466225]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb - - 7.3 pKi - - - J Pharmacol Exp Ther (2003) 306: 463-70 [PMID:12721327]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]