PGD2 [Ligand Id: 1881] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1235252
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5]
  • OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
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  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
  • DP1 receptor in Mouse [GtoPdb: 338] [UniProtKB: P70263]
  • DP1 receptor in Rat [GtoPdb: 338] [UniProtKB: Q9R261]
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  • DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
  • DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
  • DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
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  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
  • EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
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  • EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
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  • EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
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  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
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  • FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
  • FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.42 pKi 38 nM Ki Am J Physiol (1999) 277: R734-R741 [PMID:10484490]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073699] [GtoPdb: 1223] [UniProtKB: Q9EPT5]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.01 pKi 98 nM Ki Am J Physiol (1999) 277: R734-R741 [PMID:10484490]
OATP2A1/Solute carrier organic anion transporter family member 2A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073680] [GtoPdb: 1223] [UniProtKB: Q00910]
ChEMBL TP_TRANSPORTER: inhibition of PGE2 uptake in PGT-expressing HeLa cells F 7.35 pKi 45 nM Ki Am J Physiol (1999) 277: R734-R741 [PMID:10484490]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 9.2 pKi - - - Eur J Pharmacol (1999) 377: 101-15 [PMID:10448933];
J Biol Chem (1995) 270: 18910-6 [PMID:7642548];
Br J Pharmacol (1998) 123: 1317-24 [PMID:9579725];
Br J Pharmacol (2006) 148: 326-39 [PMID:16604093]
DP1 receptor in Mouse [GtoPdb: 338] [UniProtKB: P70263]
GtoPdb - - 7.7 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
DP1 receptor in Rat [GtoPdb: 338] [UniProtKB: Q9R261]
GtoPdb - - 7.6 pKi - - - Eur J Pharmacol (1999) 377: 101-15 [PMID:10448933]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 8.6 pKi - - - Br J Pharmacol (2002) 137: 1163-72 [PMID:12466225];
Eur J Pharmacol (2005) 524: 30-7 [PMID:16256979]
DP2 receptor in Mouse [GtoPdb: 339] [UniProtKB: Q9Z2J6]
GtoPdb - - 7.5 pKi - - - J Pharmacol Exp Ther (2003) 306: 463-70 [PMID:12721327];
J Biol Chem (2005) 280: 32442-32451 [PMID:16030019]
DP2 receptor in Rat [GtoPdb: 339] [UniProtKB: Q6XKD3]
GtoPdb - - 8.2 pIC50 - - - J Pharmacol Exp Ther (2003) 307: 518-25 [PMID:12975488]
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 4.7 pKi - - - J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb - - 5.2 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 5 pKi - - - Mol Pharmacol (1999) 56: 545-51 [PMID:10462542]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 5.3 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb - - 6.55 pKi 280 nM Ki Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 5.9 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 8.89 pKi 1.3 nM Ki Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 7.89 pEC50 13 nM EC50 Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 9 pKi 1 nM Ki Mol Pharmacol (1999) 56: 545-51 [PMID:10462542];
Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683]
GtoPdb - - 8.77 pEC50 1.7 nM EC50 J Pharmacol Exp Ther (2009) 331: 297-307 [PMID:19584306]
EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114]
GtoPdb - - 5.9 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb - - 7.7 pKi - - - Biochem J (2003) 371: 443-9 [PMID:12519077]
FP receptor in Mouse [GtoPdb: 344] [UniProtKB: P43117]
GtoPdb - - 7.3 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]