ChEMBL ligand: CHEMBL88402 (RS-102221)
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] 5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] 5-HT2C receptor in Rat [GtoPdb: 8] [UniProtKB: P08909] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb	-	-	6	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Neuropharmacology (1997) 36: 621-9 [PMID:9225287]
ChEMBL	Displacement of [3H]-ketanserin from human cloned 5-hydroxytryptamine 2A receptor expressed in CHO-K1 cells.	B	6.2	pKi	630.96	nM	Ki	Bioorg. Med. Chem. Lett. (1996) 6: 2687-2692
5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
GtoPdb	-	-	6.8	pKi	-	-	-	Neuropharmacology (1997) 36: 621-9 [PMID:9225287]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb	-	-	6.1	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Neuropharmacology (1997) 36: 621-9 [PMID:9225287]
ChEMBL	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	B	6.5	pKi	316.23	nM	Ki	Bioorg. Med. Chem. Lett. (1996) 6: 2687-2692
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb	-	-	8.4	pKi	3.98	nM	Ki	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Neuropharmacology (1997) 36: 621-9 [PMID:9225287]
ChEMBL	Displacement of radiolabeled RS 102221 from human 5HT2C receptor	B	8.41	pKi	3.9	nM	Ki	J. Med. Chem. (2008) 51: 7094-7098 [PMID:18983139]
ChEMBL	Displacement of [3H]mesulergine from human cloned 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells	B	8.7	pKi	2	nM	Ki	Bioorg. Med. Chem. Lett. (1996) 6: 2687-2692
ChEMBL	Binding affinity to human 5-HT2C receptor by radioligand displacement assay	B	9.04	pKi	0.91	nM	Ki	Eur. J. Med. Chem. (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in HEK293 cells	B	9.22	pKi	0.6	nM	Ki	J. Med. Chem. (2014) 57: 4543-4557 [PMID:24805037]
ChEMBL	Displacement of [3H]mesulergine from human 5-HT2C receptor expressed in HEK-293 cells	B	9.22	pKi	0.6	nM	Ki	Eur. J. Med. Chem. (2015) 92: 221-235 [PMID:25557493]
ChEMBL	Displacement of radiolabeled RS 102221 from human 5HT2C receptor	B	8.08	pIC50	8.3	nM	IC50	J. Med. Chem. (2008) 51: 7094-7098 [PMID:18983139]
ChEMBL	Binding affinity to human 5-HT2C receptor by radioligand displacement assay	B	8.26	pIC50	5.5	nM	IC50	Bioorg. Med. Chem. (2013) 21: 2764-2771 [PMID:23582449]
ChEMBL	Binding affinity to human 5-HT2C receptor by radioligand displacement assay	B	8.57	pIC50	2.7	nM	IC50	Eur. J. Med. Chem. (2013) 63: 85-94 [PMID:23466604]
ChEMBL	Displacement of [3H]mesuleregine from human recombinant 5-HT2C receptor expressed in HEK293 cells	B	8.82	pIC50	1.5	nM	IC50	Bioorg. Med. Chem. (2016) 24: 1793-1810 [PMID:26988801]
ChEMBL	Displacement of [3H]mesulergine from human recombinant 5HT2C receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	B	8.82	pIC50	1.5	nM	IC50	Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250]
5-HT2C receptor in Rat [GtoPdb: 8] [UniProtKB: P08909]
GtoPdb	-	-	8.4	pKi	-	-	-	Neuropharmacology (1997) 36: 621-9 [PMID:9225287]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]