ABT-491 [Ligand Id: 1850] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL369225 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PAF receptor/Platelet activating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Eur J Pharmacol (1997) 325: 69-80 [PMID:9151941] |
| ChEMBL | The compound was evaluated for its binding affinity against PAF receptor in human platelet | B | 9.24 | pKi | 0.57 | nM | Ki | J Med Chem (1998) 41: 74-95 [PMID:9438024] |
| Platelet activating factor receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5136] [UniProtKB: P21556] | ||||||||
| ChEMBL | The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (1998) 41: 74-95 [PMID:9438024] |
| ChEMBL | Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes | B | 9 | pKi | 1 | nM | Ki | J Med Chem (1998) 41: 74-95 [PMID:9438024] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
