[3H]PAF [Ligand Id: 1833] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1235246
  • PAF receptor/Platelet activating factor receptor in Human [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PAF receptor/Platelet activating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL250] [GtoPdb: 334] [UniProtKB: P25105]
GtoPdb - - 8.9 pKd 1.3 nM Kd J Biol Chem (1991) 266: 20400-5 [PMID:1657923];
J Biol Chem (2001) 276: 43025-30 [PMID:11560941]
ChEMBL Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs B 9.82 pKi 0.15 nM Ki Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs B 9.55 pIC50 0.28 nM IC50 Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]