UDP-glucose [Ligand Id: 1783] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL375951 (5'-Diphosphoglucose, UDPG, Udp-Glucose, Uridine-5'-Diphosphoglucose, Uridine Diphosphate Glucose) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y14 receptor/Purinergic receptor P2Y14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4518] [GtoPdb: 330] [UniProtKB: Q15391] | ||||||||
| GtoPdb | - | - | 7.1 | pIC50 | - | - | - | J Pharmacol Exp Ther (2009) 330: 162-8 [PMID:19339661] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production | F | 6.4 | pEC50 | 400 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC | F | 6.45 | pEC50 | 354 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 761-766 [PMID:17088057] |
| ChEMBL | Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis | F | 6.46 | pEC50 | 350 | nM | EC50 | J Med Chem (2007) 50: 2030-2039 [PMID:17407275] |
| ChEMBL | Agonist activity at human P2Y14 receptor expressed in human COS7 cells | F | 6.58 | pEC50 | 261 | nM | EC50 | Bioorg Med Chem (2009) 17: 5298-5311 [PMID:19502066] |
| P2Y14 receptor in Mouse [GtoPdb: 330] [UniProtKB: Q9ESG6] | ||||||||
| GtoPdb | - | - | 7.7 | pEC50 | - | - | - | Genomics (2001) 78: 124-8 [PMID:11735218] |
| P2Y14 receptor in Rat [GtoPdb: 330] [UniProtKB: O35881] | ||||||||
| GtoPdb | - | - | 7.6 | pEC50 | - | - | - | Genomics (2001) 78: 124-8 [PMID:11735218] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells | F | 5 | pEC50 | 10000 | nM | EC50 | Bioorg Med Chem (2009) 17: 5298-5311 [PMID:19502066] |
| P2Y6 receptor/Pyrimidinergic receptor P2Y6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4714] [GtoPdb: 326] [UniProtKB: Q15077] | ||||||||
| ChEMBL | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production | F | 5.8 | pEC50 | 1600 | nM | EC50 | J Med Chem (2010) 53: 471-480 [PMID:19902968] |
| GPR17 in Human [GtoPdb: 88] [UniProtKB: Q13304] | ||||||||
| GtoPdb | [35S]GTPγS binding to 1321N1 cell membranes expressing hGPR17. | - | 9.52 | pEC50 | 0.3 | nM | EC50 |
Br J Pharmacol (2010) 159: 1092-105 [PMID:20148890]; EMBO J (2006) 25: 4615-27 [PMID:16990797] |
| GPR17 in Mouse [GtoPdb: 88] [UniProtKB: Q6NS65] | ||||||||
| GtoPdb | - | - | 7.26 | pEC50 | 55 | nM | EC50 | PLoS ONE (2008) 3: e3579 [PMID:18974869] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
