BzATP [Ligand Id: 1757] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2407634 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413] | ||||||||
| ChEMBL | Competitive-inhibition of recombinant human N-terminal His-tagged soluble NPP1 (Val191 to Leu591 residues) expressed in mouse NSO cells using ATP as substrate after 30 mins by capillary electrophoresis method | B | 4.84 | pKi | 14600 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
| ChEMBL | Competitive-inhibition of recombinant human NPP1 expressed in HEK293 cell membranes using p-Nph-5'-TMP as substrate pretreated for 10 mins followed by substrate addition and measured after 60 mins by capillary electrophoresis method | B | 5.53 | pKi | 2960 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295913] [UniProtKB: Q924C3] | ||||||||
| ChEMBL | Competitive-inhibition of Wistar rat NPP1 using p-Nph-5'-TMP as substrate measured after 5 mins by UPLC method | B | 4.69 | pKi | 20500 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
| P2Y11 receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
| GtoPdb | - | - | 5.1 | pEC50 | - | - | - | Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132] |
| P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572] | ||||||||
| GtoPdb | Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. | - | 5.33 | pEC50 | 4677 | nM | EC50 | Br J Pharmacol (2009) 157: 1203-14 [PMID:19558545] |
| P2X7 in Mouse [GtoPdb: 484] [UniProtKB: Q9Z1M0] | ||||||||
| GtoPdb | Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. | - | 4 | pEC50 | 100000 | nM | EC50 | Br J Pharmacol (2009) 157: 1203-14 [PMID:19558545] |
| P2X7 in Rat [GtoPdb: 484] [UniProtKB: Q64663] | ||||||||
| GtoPdb | Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. | - | 5 | pEC50 | 10000 | nM | EC50 | Br J Pharmacol (2009) 157: 1203-14 [PMID:19558545] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
