reactive blue-2 | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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reactive blue-2
Ligand Activity Charts

reactive blue-2 [Ligand Id: 1739] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1160031 (Reactive Blue 2)
choline O-acetyltransferase/Choline acetylase in Human [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329] There should be some charts here, you may need to enable JavaScript!
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human [ChEMBL: CHEMBL5925] [UniProtKB: P22413] There should be some charts here, you may need to enable JavaScript!
P2Y₂ receptor in Human [GtoPdb: 324] [UniProtKB: P41231] There should be some charts here, you may need to enable JavaScript!
P2Y₄ receptor in Rat [GtoPdb: 325] [UniProtKB: O35811] There should be some charts here, you may need to enable JavaScript!
P2Y₆ receptor in Human [GtoPdb: 326] [UniProtKB: Q15077] There should be some charts here, you may need to enable JavaScript!
P2Y₁₁ receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91] There should be some charts here, you may need to enable JavaScript!
P2Y₁₃ receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
ChEMBL	Inhibition of choline acetyltransferase isolated from squid head ganglia	B	6.1	pKi	800	nM	Ki	J Med Chem (1981) 24: 1534-1537 [PMID:7310833]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413]
ChEMBL	Competitive inhibition of human NPP1 expressed in African green monkey COS7 cells using ATP as substrate after 20 mins by Michaelis-Menten plot analysis	B	6.28	pKi	520	nM	Ki	Bioorg Med Chem (2016) 24: 3157-3165 [PMID:27265686]
P2Y₂ receptor in Human [GtoPdb: 324] [UniProtKB: P41231]
GtoPdb	-	-	6	pIC50	-	-	-	Br J Pharmacol (1999) 127: 709-16 [PMID:10401562]
P2Y₄ receptor in Rat [GtoPdb: 325] [UniProtKB: O35811]
GtoPdb	-	-	4.7	pIC50	-	-	-	Br J Pharmacol (1998) 124: 428-30 [PMID:9647463]
P2Y₆ receptor in Human [GtoPdb: 326] [UniProtKB: Q15077]
GtoPdb	-	-	4.5	pIC50	31000	nM	IC50	Curr Med Chem (2006) 13: 289-312 [PMID:16475938]
P2Y₁₁ receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91]
GtoPdb	-	-	5	pIC50	-	-	-	Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132]
P2Y₁₃ receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
GtoPdb	-	-	5.7	pIC50	-	-	-	Mol Pharmacol (2003) 64: 104-12 [PMID:12815166]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]