VER-3323 [Ligand Id: 168] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL309760 (VER-3323) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
| ChEMBL | Affinity for human 5-hydroxytryptamine 2A receptor expressed in mammalian cell line | B | 6.45 | pKi | 351 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| ChEMBL | Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader | F | 6.14 | pEC50 | 719 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line | B | 7.34 | pKi | 46 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| GtoPdb | - | - | 7.5 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
| ChEMBL | Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader | F | 7.96 | pEC50 | 11 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell line | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
| GtoPdb | - | - | 8.2 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
| ChEMBL | Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader | F | 7.36 | pEC50 | 44 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
