ChEMBL ligand: CHEMBL76781 (Ro-600175, Ro-60-0175)
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb	-	-	7.4	pKi	-	-	-	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
ChEMBL	Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cells	B	7.41	pKi	39	nM	Ki	Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544]
ChEMBL	Affinity for human 5-hydroxytryptamine 2A receptor expressed in mammalian cell line	B	7.42	pKi	38	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL	Displacement of [125I]DOI from human 5HT2A	B	7.42	pKi	38	nM	Ki	Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207]
ChEMBL	Binding affinity against human 5-hydroxytryptamine 2A receptor using displacement of [3H]5-HT	B	7.5	pKi	31.62	nM	Ki	J Med Chem (1997) 40: 2762-2769 [PMID:9276022]
ChEMBL	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	F	6.4	pEC50	400	nM	EC50	Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544]
ChEMBL	Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometric imaging plate reader	F	6.88	pEC50	131	nM	EC50	Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL	Binding to human 5HT2A receptor expressed in CHO cells	B	6.88	pEC50	131	nM	EC50	Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207]
ChEMBL	Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	F	7.3	pEC50	50.12	nM	EC50	J Med Chem (2008) 51: 305-313 [PMID:18095642]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	B	8.29	pKi	5.1	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL	Displacement of [3H]5-HT from human 5HT2B	B	8.29	pKi	5.1	nM	Ki	Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207]
GtoPdb	-	-	8.3	pKi	5.01	nM	Ki	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
ChEMBL	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	F	8.37	pEC50	4.3	nM	EC50	Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL	Binding to human 5HT2B receptor expressed in CHO cells	B	8.37	pEC50	4.3	nM	EC50	Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207]
ChEMBL	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	F	8.62	pEC50	2.4	nM	EC50	Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544]
ChEMBL	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	F	8.8	pEC50	1.58	nM	EC50	J Med Chem (2008) 51: 305-313 [PMID:18095642]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cells	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544]
GtoPdb	-	-	8.2	pKi	6.31	nM	Ki	Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Eur J Pharmacol (2004) 483: 37-43 [PMID:14709324]
ChEMBL	Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell line	B	8.64	pKi	2.3	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL	Displacement of [3H]5-HT from human 5HT2C	B	8.64	pKi	2.3	nM	Ki	Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207]
ChEMBL	Binding affinity against human 5-hydroxytryptamine 2C receptor using displacement of [3H]DOB	B	8.9	pKi	1.26	nM	Ki	J Med Chem (1997) 40: 2762-2769 [PMID:9276022]
ChEMBL	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	F	7.28	pEC50	52	nM	EC50	Bioorg Med Chem (2008) 16: 1966-1982 [PMID:18035544]
ChEMBL	Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometric imaging plate reader	F	7.74	pEC50	18	nM	EC50	Bioorg Med Chem Lett (2004) 14: 2367-2370 [PMID:15081042]
ChEMBL	Binding to human 5HT2C receptor expressed in CHO cells	B	7.74	pEC50	18	nM	EC50	Bioorg Med Chem Lett (2006) 16: 677-680 [PMID:16257207]
ChEMBL	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	F	8.4	pEC50	3.98	nM	EC50	J Med Chem (2008) 51: 305-313 [PMID:18095642]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL	Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat	F	6.7	pEC50	199.53	nM	EC50	J Med Chem (1997) 40: 2762-2769 [PMID:9276022]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]