CGP 71683A [Ligand Id: 1562] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL195380
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  • Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AQP1/Aquaporin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523210] [GtoPdb: 688] [UniProtKB: P29972]
ChEMBL Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assay B 5.57 pIC50 2700 nM IC50 Eur J Med Chem (2020) 208: 112855-112855 [PMID:33007663]
Y5 receptor in Rat [GtoPdb: 308] [UniProtKB: Q63634]
GtoPdb - - 9.5 pKi - - - Br J Pharmacol (2003) 139: 1360-8 [PMID:12890716]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]