ChEMBL ligand: CHEMBL1672380 (1-Adamantanecarbonyl-RF-NH2)
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2] Mas-related G-protein coupled receptor member X1 in Mouse [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3] Mas-related G-protein coupled receptor member X1 in Rat [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1] There should be some charts here, you may need to enable JavaScript!
kisspeptin receptor/Metastin receptor in Human [ChEMBL: CHEMBL5413] [GtoPdb: 266] [UniProtKB: Q969F8] There should be some charts here, you may need to enable JavaScript!
NPFF1 receptor/Neuropeptide FF receptor 1 in Human [ChEMBL: CHEMBL5951] [GtoPdb: 300] [UniProtKB: Q9GZQ6] There should be some charts here, you may need to enable JavaScript!
NPFF2 receptor/Neuropeptide FF receptor 2 in Human [ChEMBL: CHEMBL5952] [GtoPdb: 301] [UniProtKB: Q9Y5X5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
ChEMBL	Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay	B	4	pEC50	>100000	nM	EC50	Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
Mas-related G-protein coupled receptor member X1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
ChEMBL	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	B	6.5	pEC50	316.23	nM	EC50	Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
Mas-related G-protein coupled receptor member X1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
ChEMBL	Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay	B	5.2	pEC50	6309.57	nM	EC50	Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
kisspeptin receptor/Metastin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5413] [GtoPdb: 266] [UniProtKB: Q969F8]
ChEMBL	Displacement of [125I]kisspeptin-15 from GPR54	B	6.08	pIC50	830	nM	IC50	ACS Med Chem Lett (2011) 2: 53-57 [PMID:24900254]
NPFF1 receptor/Neuropeptide FF receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5951] [GtoPdb: 300] [UniProtKB: Q9GZQ6]
GtoPdb	-	-	7.2	pKi	-	-	-	Proc Natl Acad Sci USA (2006) 103: 466-71 [PMID:16407169]
ChEMBL	Displacement of [125I]YVP from human NPFFR1 expressed in CHO cells	B	7.24	pKi	58	nM	Ki	J Med Chem (2020) 63: 12387-12402 [PMID:32673481]
ChEMBL	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7471-7474 [PMID:23131340]
ChEMBL	Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method	B	7.85	pKi	14	nM	Ki	J Med Chem (2021) 64: 7555-7564 [PMID:34008968]
ChEMBL	Antagonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as reversal of NPPF induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem (2019) 27: 630-643 [PMID:30626554]
ChEMBL	Antagonist activity at human NPFFR1 expressed in CHO cells assessed as reversal of NPVF-induced inhibition of forskolin-stimulated cAMP accumulation incubated for 10 mins by liquid scintillation counting method	F	5.33	pEC50	4700	nM	EC50	J Med Chem (2020) 63: 12387-12402 [PMID:32673481]
ChEMBL	Agonist activity at human NPFF1 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	6.34	pEC50	462	nM	EC50	J Med Chem (2012) 55: 6124-6136 [PMID:22708927]
ChEMBL	Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	7.15	pEC50	71	nM	EC50	J Med Chem (2012) 55: 6124-6136 [PMID:22708927]
NPFF2 receptor/Neuropeptide FF receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5952] [GtoPdb: 301] [UniProtKB: Q9Y5X5]
GtoPdb	-	-	7.1	pKi	-	-	-	Proc Natl Acad Sci USA (2006) 103: 466-71 [PMID:16407169]
ChEMBL	Displacement of [125I]Tyr-NPFF from human NPFFR2 expressed in green monkey Cos-1 cells	B	7.12	pKi	75	nM	Ki	J Med Chem (2020) 63: 12387-12402 [PMID:32673481]
ChEMBL	Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7471-7474 [PMID:23131340]
ChEMBL	Displacement of [125I]-1DMeNPFF from recombinant human NPFF2 receptor expressed in CHO cells by TopCount scintillation counting method	B	7.74	pKi	18	nM	Ki	J Med Chem (2021) 64: 7555-7564 [PMID:34008968]
ChEMBL	Antagonist activity at NPFF2 receptor (unknown origin) expressed in HEK293A cells assessed as reversal of NPPF induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins	F	6.39	pIC50	410	nM	IC50	Bioorg Med Chem (2019) 27: 630-643 [PMID:30626554]
ChEMBL	Agonist activity at human NPFF2 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	6.33	pEC50	472	nM	EC50	J Med Chem (2012) 55: 6124-6136 [PMID:22708927]
ChEMBL	Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting	F	6.42	pEC50	379	nM	EC50	J Med Chem (2012) 55: 6124-6136 [PMID:22708927]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]