fangchinoline [Ligand Id: 14520] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL504256 (NSC-77036) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs | F | 6.51 | pIC50 | 306 | nM | IC50 | J Nat Prod (1999) 62: 59-66 [PMID:9917283] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs | F | 6.75 | pIC50 | 179 | nM | IC50 | J Nat Prod (1999) 62: 59-66 [PMID:9917283] |
| CYP3A4 in Human [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
| GtoPdb | Measuring inhibition of CYP3A4-mediated metabolism of abemaciclib in human liver microsomes | - | 4.91 | pIC50 | 12240 | nM | IC50 | Arabian J of Chemistry (2024) 18: 106073 |
| CYP3A4 in Rat [GtoPdb: 1337] | ||||||||
| GtoPdb | Measuring inhibition of CYP3A4-mediated metabolism of abemaciclib in rat liver microsomes | - | 5.69 | pIC50 | 2020 | nM | IC50 | Arabian J of Chemistry (2024) 18: 106073 |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
