ryanozole [Ligand Id: 14481] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL5639852
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  • RyR2 in Mouse [GtoPdb: 748] [UniProtKB: Q9ERN6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ryanodine receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4745] [UniProtKB: E9Q401]
ChEMBL Inhibition of Full length wild type mouse RyR2 expressed in Flp-In-T-REx-293 cells assessed as increase in Ca2+ release endoplasmic reticulum by flex-station 3 fluorometer analysis B 7.89 pEC50 13 nM EC50 Eur J Med Chem (2023) 262: 115910-115910 [PMID:37922828]
RyR2 in Mouse [GtoPdb: 748] [UniProtKB: Q9ERN6]
GtoPdb Determined as as increase in Ca2+ release from endoplasmic reticulum in cells expressing full length wild type mouse RyR2 - 7.89 pEC50 13 nM EC50 Eur J Med Chem (2023) 262: 115910 [PMID:37922828]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]