USP28 inhibitor 9p [Ligand Id: 14187] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5401467 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ubiquitin specific peptidase 28/Ubiquitin carboxyl-terminal hydrolase 28 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157853] [GtoPdb: 3325] [UniProtKB: Q96RU2] | ||||||||
| ChEMBL | Inhibition of USP28 (149 to 703 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using Ub-AMC as substrate by fluorescence based analysis | B | 7.4 | pIC50 | 40 | nM | IC50 | Eur J Med Chem (2023) 254: 115369-115369 [PMID:37075624] |
| GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | Eur J Med Chem (2023) 254: 115369 [PMID:37075624] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
