selatogrel [Ligand Id: 14164] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297589 (ACT-246475, Selatogrel, Act-246475) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y12 receptor/P2Y purinoceptor 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| GtoPdb | - | - | 8.7 | pKd | - | - | - |
Platelets (2022) 33: 147-156 [PMID:33427002]; J Med Chem (2025) 68: 9057-9083 [PMID:40289379] |
| ChEMBL | Binding affinity to human P2Y12R expressed in CHO cells assessed as dissociation constant SPR assay | B | 8.82 | pKd | 1.5 | nM | Kd | J Med Chem (2025) 68: 9057-9083 [PMID:40289379] |
| GtoPdb | Determined as displacement of [33P]-2MeSADP from P2Y12 receptors expressed in CHO cells | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2015) 58: 9133-53 [PMID:26550844] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
