L-serine-O-phosphate [Ligand Id: 1411] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL284377 (Dexfosfoserina, Dexfosfoserine, Dl-o-phosphorylserine, Dl-phosphoserine, Energoserina, Fosforina, GNF-PF-1028, L-o-phosphoserine, L-o-serine phosphate, L-phosphoserine, NSC-760136, NSC-90791, O-phosphoryl-l-serine, O-phosphoserine, l-, Phosphoserine, dl-, Serine phosphate, Seriphos, Serophen) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Concentration for half maximal activation of metabotropic glutamate mGluR4a in human | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (1995) 38: 1417-1426 [PMID:7738999] |
| GtoPdb | - | - | 5.9 | pEC50 | 1420 | nM | EC50 | Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604] |
| ChEMBL | Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay | B | 6 | pEC50 | 1000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1447-1450 [PMID:10888329] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| GtoPdb | - | - | 6.2 | pIC50 | - | - | - |
J Neurosci (1993) 13: 1372-8 [PMID:8463825]; Neuropharmacology (1997) 36: 21-30 [PMID:9144638]; Br J Pharmacol (1995) 116: 3279-87 [PMID:8719808]; J Biol Chem (1999) 274: 10008-13 [PMID:10187777]; Neuroreport (1993) 4: 1099-101 [PMID:8106006] |
| ChEMBL | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active | F | 4 | pEC50 | <100000 | nM | EC50 | J Med Chem (2005) 48: 2534-2547 [PMID:15801843] |
| ChEMBL | Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat | B | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (1995) 38: 1417-1426 [PMID:7738999] |
| mGlu6 receptor in Human [GtoPdb: 294] [UniProtKB: O15303] | ||||||||
| GtoPdb | - | - | 6.4 | pEC50 | - | - | - | Neuropharmacology (1997) 36: 145-52 [PMID:9144651] |
| mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349] | ||||||||
| ChEMBL | Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat | B | 5.57 | pEC50 | 2700 | nM | EC50 | J Med Chem (1995) 38: 1417-1426 [PMID:7738999] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | F | 5.97 | pEC50 | 1080 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | F | 5.97 | pEC50 | >1065 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831] | ||||||||
| GtoPdb | - | - | 4.4 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2000) 362: 546-54 [PMID:11138847] |
| GtoPdb | - | - | 4.5 | pEC50 | 31000 | nM | EC50 | Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604] |
| mGlu8 receptor in Human [GtoPdb: 296] [UniProtKB: O00222] | ||||||||
| GtoPdb | - | - | 7.2 | pIC50 | - | - | - |
Brain Res Mol Brain Res (1998) 53: 88-97 [PMID:9473604]; Brain Res Mol Brain Res (1999) 67: 201-10 [PMID:10216218] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
