4-MPPTS [Ligand Id: 1402] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL108939 (LY-487379) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| ChEMBL | Ability to displace [3H]LY-341,495 at glutamate-site on Metabotropic glutamate receptor 2; No significant displacement | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2003) 46: 3189-3192 [PMID:12852748] |
| GtoPdb | - | - | 5.8 | pIC50 | - | - | - |
J Med Chem (2003) 46: 3189-92 [PMID:12852748]; Mol Pharmacol (2003) 64: 798-810 [PMID:14500736]; Psychopharmacology (Berl.) (2005) 179: 271-83 [PMID:15717213]; Bioorg Med Chem Lett (2004) 14: 3099-102 [PMID:15149652] |
| ChEMBL | Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]GTP gamma S binding assay | F | 5.77 | pEC50 | 1700 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 5867-5872 [PMID:15501058] |
| ChEMBL | Effective concentration for binding to human metabotropic glutamate receptor 2 as determined by GTPgammaS assay | B | 5.77 | pEC50 | 1700 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 5329-5332 [PMID:15454221] |
| ChEMBL | Effective concentration against Metabotropic glutamate receptor 2 | B | 6.57 | pEC50 | 270 | nM | EC50 | J Med Chem (2003) 46: 3189-3192 [PMID:12852748] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
