nizubaglustat [Ligand Id: 13906] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3354637 (Nizubaglustat)
  • glucosylceramidase beta/Beta-glucocerebrosidase in Human [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
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  • UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739]
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  • maltase-glucoamylase/Maltase-glucoamylase in Human [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glucosylceramidase beta/Beta-glucocerebrosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2179] [GtoPdb: 2978] [UniProtKB: P04062]
ChEMBL Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry B 5.22 pIC50 6000 nM IC50 J Med Chem (2014) 57: 9096-9104 [PMID:25250725]
Beta-glucosidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3761] [UniProtKB: Q9HCG7]
ChEMBL Inhibition of GBA2 (unknown origin) B 9.22 pIC50 0.6 nM IC50 J Med Chem (2014) 57: 9096-9104 [PMID:25250725]
UDP-glucose ceramide glucosyltransferase/Ceramide glucosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2063] [GtoPdb: 2528] [UniProtKB: Q16739]
GtoPdb - - 8.6 pIC50 2.5 nM IC50 J Med Chem (2014) 57: 9096-104 [PMID:25250725]
ChEMBL Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide B 8.6 pIC50 2.5 nM IC50 J Med Chem (2014) 57: 9096-9104 [PMID:25250725]
Lactase-phlorizin hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075131] [UniProtKB: P09848]
ChEMBL Inhibition of intestinal lactase (unknown origin) B 4.3 pIC50 50000 nM IC50 J Med Chem (2014) 57: 9096-9104 [PMID:25250725]
maltase-glucoamylase/Maltase-glucoamylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2074] [GtoPdb: 2627] [UniProtKB: O43451]
ChEMBL Inhibition of intestinal maltase (unknown origin) B 4 pIC50 >100000 nM IC50 J Med Chem (2014) 57: 9096-9104 [PMID:25250725]
Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410]
ChEMBL Inhibition of intestinal sucrase (unknown origin) B 4 pIC50 >100000 nM IC50 J Med Chem (2014) 57: 9096-9104 [PMID:25250725]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]