ChEMBL ligand: CHEMBL395280
Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275] acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] Acetylcholinesterase in Bovine [ChEMBL: CHEMBL4768] [UniProtKB: P23795] acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] Butyrylcholinesterase in Rat [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as a substrate incubated for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method	B	4.96	pIC50	11000	nM	IC50	J Nat Prod (2021) 84: 2374-2379 [PMID:34445873]
ChEMBL	Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's method	B	5.29	pIC50	5170	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126985-126985 [PMID:32008906]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Binding affinity to CM5 sensor chip immobilized recombinant human AChE assessed as dissociation constant at 298.15 K by surface plasmon resonance assay	B	7.77	pKd	17	nM	Kd	J Med Chem (2021) 64: 1844-1855 [PMID:33570950]
GtoPdb	-	-	7.77	pKd	17	nM	Kd	J Med Chem (2021) 64: 1844-1855 [PMID:33570950]
ChEMBL	Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by DTNB reagent based Ellman's method	B	5.28	pIC50	5280	nM	IC50	Bioorg Med Chem Lett (2022) 72: 128873-128873 [PMID:35779827]
ChEMBL	Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate after 5 mins by spectrophotometric analysis	B	5.37	pIC50	4300	nM	IC50	J Nat Prod (2019) 82: 792-797 [PMID:30794407]
ChEMBL	Inhibition of human acetylcholinesterase after 30 mins by microplate reader-based Ellman's method	B	6.22	pIC50	600	nM	IC50	J Nat Prod (2015) 78: 3067-3070 [PMID:26618211]
ChEMBL	Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by Ellman's method	B	6.4	pIC50	400	nM	IC50	J Nat Prod (2018) 81: 2115-2119 [PMID:30183289]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's method	B	7.48	pIC50	33	nM	IC50	J Nat Prod (2019) 82: 239-248 [PMID:30701972]
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL	Inhibition of bovine erythrocytes AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's methods	B	7	pIC50	100	nM	IC50	J Nat Prod (2020) 83: 2831-2843 [PMID:32941036]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
ChEMBL	Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 20 mins by by Ellman's method	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2018) 26: 3117-3125 [PMID:29729987]
ChEMBL	Inhibition of AChE in rat cortex homogenate using acetylthiocholine iodide as substrate after 20 mins by Ellman's method	B	7.01	pIC50	98	nM	IC50	Eur J Med Chem (2018) 143: 33-47 [PMID:29172081]
ChEMBL	Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 20 mins by Ellman's method	B	7.09	pIC50	82	nM	IC50	J Med Chem (2016) 59: 8326-8344 [PMID:27552582]
ChEMBL	Inhibition of rat cortex homogenate acetylcholinesterase by spectrophotometric method	B	7.09	pIC50	82	nM	IC50	Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's method	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2019) 82: 239-248 [PMID:30701972]
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1]
ChEMBL	Inhibition of rat cortex homogenate BuChE by spectrophotometric method	B	4.13	pIC50	74430	nM	IC50	Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080]
ChEMBL	Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate after 20 mins by by Ellman's method	B	4.44	pIC50	36400	nM	IC50	Bioorg Med Chem (2018) 26: 3117-3125 [PMID:29729987]
ChEMBL	Inhibition of BuChE in rat serum using butyrylthiocholine iodide as substrate after 20 mins by Ellman's method	B	4.44	pIC50	36400	nM	IC50	Eur J Med Chem (2018) 143: 33-47 [PMID:29172081]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]