ChEMBL ligand: CHEMBL1171146 (Sarsasapogenin)
Amyloid-beta A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
OATP1B1 in Human [GtoPdb: 1220] [UniProtKB: Q9Y6L6] There should be some charts here, you may need to enable JavaScript!
OATP1B3 in Human [GtoPdb: 1221] [UniProtKB: Q9NPD5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation after 24 hrs by thioflavin-T fluorescence assay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2018) 151: 351-362 [PMID:29635167]
OATP1B1 in Human [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
GtoPdb	Inhibition of substrate uptake in CHO cells expressing hOATP1B1	-	6.89	pKi	130	nM	Ki	Mol Pharmacol (2013) 83: 1257-67 [PMID:23571415]
OATP1B3 in Human [GtoPdb: 1221] [UniProtKB: Q9NPD5]
GtoPdb	Inhibition of substrate uptake in CHO cells expressing hOATP1B3	-	7.1	pKi	80	nM	Ki	Mol Pharmacol (2013) 83: 1257-67 [PMID:23571415]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]