ChEMBL ligand: CHEMBL292821
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] There should be some charts here, you may need to enable JavaScript!
TA1 receptor/Trace amine-associated receptor 1 in Human [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Affinity against 5-hydroxytryptamine 2A receptor (K) labeled with [3H]ketanserin.	B	7.47	pKi	34	nM	Ki	J Med Chem (1994) 37: 1929-1935 [PMID:8027974]
ChEMBL	Affinity against 5-hydroxytryptamine 2A receptor (D) labeled with [125I]DOI.	B	9	pKi	1	nM	Ki	J Med Chem (1994) 37: 1929-1935 [PMID:8027974]
GtoPdb	-	-	9.18	pKi	0.66	nM	Ki	J Med Chem (2006) 49: 5794-803 [PMID:16970404]
ChEMBL	Displacement of (+/-)-[125I]DOI from human cloned 5HT2A receptor	B	9.18	pKi	0.66	nM	Ki	J Med Chem (2006) 49: 5794-5803 [PMID:16970404]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL	Displacement of [3H]ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptor	B	7.8	pKi	16	nM	Ki	J Med Chem (2000) 43: 3074-3084 [PMID:10956215]
ChEMBL	Displacement of (+/-)-[125I]DOI from rat cloned 5HT2A receptor	B	9.06	pKi	0.88	nM	Ki	J Med Chem (2006) 49: 5794-5803 [PMID:16970404]
ChEMBL	Activity at rat 5HT2A receptor expressed in NIH3T3 cells assessed as stimulation of phospholipase C-mediated IP production	F	7.57	pEC50	27	nM	EC50	J Med Chem (2006) 49: 5794-5803 [PMID:16970404]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL	Displacement of [3H]mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptor	B	6.72	pKi	190	nM	Ki	J Med Chem (2000) 43: 3074-3084 [PMID:10956215]
ChEMBL	Affinity against 5-hydroxytryptamine 2C receptor in J1 cells transfected with the rat 5-HT2C gene labeled with [3H]mesulergine.	B	7.44	pKi	36	nM	Ki	J Med Chem (1994) 37: 1929-1935 [PMID:8027974]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine as radioligand	B	7.44	pKi	36	nM	Ki	J Med Chem (1992) 35: 734-740 [PMID:1542100]
TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0]
ChEMBL	Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay	F	5.14	pEC50	7190	nM	EC50	Bioorg Med Chem (2008) 16: 7415-7423 [PMID:18602830]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]