compound 3k [PMID: 28688274] [Ligand Id: 13523] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4128703 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| pyruvate kinase M1/2/Pyruvate kinase isozymes M1/M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618] | ||||||||
| GtoPdb | Inhibition of PKM2 catalysis in a fluorescent PK-LDH coupled assay. | - | 5.53 | pIC50 | 2950 | nM | IC50 | Eur J Med Chem (2017) 138: 343-352 [PMID:28688274] |
| ChEMBL | Inhibition of recombinant human N-terminal His-tagged PKM2 expressed in Escherichia coli BL21 preincubated for 15 mins followed by PEP/NADH addition measured at 30 secs interval for 3 to 6 mins by fluorescent PK-LDH assay | B | 5.53 | pIC50 | 2950 | nM | IC50 | Eur J Med Chem (2017) 138: 343-352 [PMID:28688274] |
| ChEMBL | Inhibition of PKM2 (unknown origin) | B | 5.53 | pIC50 | 2950 | nM | IC50 | RSC Med Chem (2021) 12: 1121-1141 [PMID:34355179] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
