zeprumetostat [Ligand Id: 13512] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| enhancer of zeste 2 polycomb repressive complex 2 subunit in Human [GtoPdb: 2654] [UniProtKB: Q15910] | ||||||||
| GtoPdb | Inhibition of EZH2A677G-catalysed H3K27Me3 methylation | - | 8.24 | pIC50 | 5.7 | nM | IC50 | WO2017084494A1. Benzofuran derivative, preparation method thereof and use thereof in medicine (2017) |
| GtoPdb | Inhibition of EZH2Y641F-catalysed H3K27Me3 methylation | - | 8.4 | pIC50 | 4 | nM | IC50 | WO2017084494A1. Benzofuran derivative, preparation method thereof and use thereof in medicine (2017) |
| GtoPdb | Inhibition of WT EZH2 methyltransferase activity | - | 9.06 | pIC50 | 0.87 | nM | IC50 | Cancers (Basel) (2021) 13: [PMID:34503063] |
| enhancer of zeste 1 polycomb repressive complex 2 subunit in Human [GtoPdb: 2835] [UniProtKB: Q92800] | ||||||||
| GtoPdb | Inhibition of WT EZH1 methyltransferase activity | - | 7.72 | pIC50 | 19.1 | nM | IC50 | Cancers (Basel) (2021) 13: [PMID:34503063] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
